:: Volume 24, Issue 3 (7-2012) ::
J Iran Dent Assoc 2012, 24(3): 122-138 Back to browse issues page
Effects of Different Growth Factors on New Bone Formation: A Systematic Review
Hosain Behnia1, Arash Khojasteh *2, Mohammad Esmaeelinejad3, Navid Naghdi4
1- Professor and Chairman , Department of Oral and Maxillofacial Surgery , School of Dentistry , Shahid Beheshti University of Medical Sciences . Tehran, Iran
2- Assistant Professor, Department of Oral and Maxillofacial Surgery , School of Dentistry , Shahid Beheshti University of Medical Sciences And Head of the Division of Basic Sciences, Dental Research Center . Tehran, Iran , arashkhojasteh@gmail.com
3- Resident of Oral and Maxillofacial Surgery Shahid Beheshti University of Medical Sciences . Tehran, Iran .
4- Resident of Oral and Maxillofacial Surgery , Isfehan University of Medical Sciences . Isfehan, Iran
Abstract:   (11749 Views)

  Background and Aim: Using different osteogenic growth factors, which is still under investigation, is a favorable method for bone regeneration. This systematic review is aimed at evaluating the effects of different growth factors and their carriers on osteogenesis .

  Materials and Methods: Electronic databases (Medline, EMBase and Cochrane) were studied by the authors for articles published from 1999 to October 2010. Clinical and animal studies evaluating bone formation by applying a specific growth factor and the related carrier were included in this investigation. Obtained data were organized in a table and evaluated through a qualitative analysis .

  Results: Sixty-nine studies most of which evaluated the effects of BMP-2 osteogenesis in different models were included in this study. Totally, twenty-five carriers were applied with different growth factors in the experiments. Among these carriers, poly lactic– co glycolic acid (PLGA), hydroxy apatite/tricalcium phosphate/absorbable collagen sponge (HA/TCP/ACS) and BioOss were the most frequently used carriers with the growth factors in bone regeneration studies.

  Conclusion: The current evidence, although not strong enough, confirms that BMP-2 has more favorable results in osteogenesis compared with other factors. The carrier scaffold, methods of measurement (histologic or radiographic), type of animal, defect diameter and the length of follow-up are the variables that should be matched before reaching definite results for the effect of growth factors in bone regeneration .


Keywords: Growth factors, Bone regeneration, New bone formation, Carrier, BMP
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Type of Study: Orginal | Subject: Oral and Maxillofacial
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