Mental Neuropathy as Initial Manifestation of Metastatic Breast Cancer: A Case Report and Review of the Literature

Agha-Hosseini , Farzaneh; Rohani , Bita

doi:10.30699/jidai.29.1.36

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Volume 29, Issue 1 (1-2017)

J Iran Dent Assoc 2017, 29(1): 36-43

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Mental Neuropathy as Initial Manifestation of Metastatic Breast Cancer: A Case Report and Review of the Literature

Farzaneh Agha-Hosseini¹

, Bita Rohani ^*

1- Professor, Fellowship of Research Biology, Dental Research Center, Dental Research Institute AND Department of Oral and Maxil-lofacial Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
2- Assistant Professor, Department of Oral Medicine, School of Dentistry, AJA University of Medical Sciences, Tehran, Iran , rohanibita@gmail.com

Abstract: (2601 Views)

Introduction: Mental neuropathy is a sensory neuropathy characterized by hypoesthe-sia or paresthesia of the chin and lower lip. It can be a symptom of a latent malignant disease.

Case Presentation: This report presents a case of a 34-year-old woman with a history of breast cancer who complained of severe pain and numbness of the right lower lip. We reviewed numerous reliable articles (through PubMed and Google Search) in relation to mental neuropathy and its possible causes.
Conclusion: Given that the reports of mental neuropathy have often been associated with malignancies, patients that complain of sensory impairment and numbness of the mental region should be examined carefully.

Keywords: Breast Neoplasms, Neoplasm Metastasis, Neuropathy, Paresthesia

Full-Text [PDF 326 kb] (1659 Downloads)

Type of Study: Review | Subject: Oral Medicine

References

1. Zaheer F, Hussain K, Rao J. Unusual presentation of 'numb chin syndrome' as the manifestation of metastatic adenocarcinoma of the lung. Int J Surg Case Rep 2013;4(12):1097-9.

2. Laurencet FM, Anchisi S, Tullen E, Dietrich PY. Mental neuropathy: report of five cases and re-view of the literature. Crit Rev Oncol Hematol. 2000 Apr;34(1):71-9.

3. Divya KS, Moran NA, Atkin PA. Numb chin syndrome: a case series and discussion. Br Dent J. 2010 Feb 27;208(4):157-60.

4. Colella G, Giudice A, Siniscalchi G, Falcone U, Guastafierro S. Chin numbness: a symptom that should not be underestimated: a review of 12 cases. Am J Med Sci. 2009 Jun;337(6):407-10.

5. Orhan K, Bayndr H, Aksoy S, Seker BK, Berberoğlu A, Ozan O. Numb chin syndrome as a manifestation of possible breast cancer metas-tasis around dental implants. J Craniofac Surg. 2011 May;22(3):942-5.

6. Yoshioka I, Shiiba S, Tanaka T, Nishikawa T, Sakamoto E, Kito S, et al. The importance of clinical features and computed tomographic findings in numb chin syndrome: a report of two cases. J Am Dent Assoc. 2009 May;140(5):550-4.

7. Smith SF, Blackman G, Hopper C. Numb chin syndrome: a nonmetastatic neurological manifestation of malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Mar;105(3): e53-6.

8. Furukawa T. Numb chin syndrome in the elderly. J Neurol Neurosurg Psychiatry. 1990 Feb; 53(2):173.

9. Barman B, Bhattacharya PK, Wankhar B, Warjri SB, Beyong T. Metastatic Breast Carcinoma Associated with Numb Chin Syndrome. Journal of Case Reports. 2014;4(2):520-3.

10. Montero Pérez FJ, González NM, Oria Pino A, Luna Morales S, Cosano Santiago JM, del Cam-po Vázquez P. [Chin numbness as initial manifestation of systemic cancer]. An Med In-terna. 2003 Sep;20(9):480-2.

11. Furukawa T. Charles Bell's description of numb chin syndrome. Neurology. 1988 Feb;38(2): 331.

12. Burt RK, Sharfman WH, Karp BI, Wilson WH. Mental neuropathy (numb chin syndrome). A harbinger of tumor progression or relapse. Can-cer. 1992 Aug 15;70(4):877-81.

13. Lossos A, Siegal T. Numb chin syndrome in cancer patients: etiology, response to treatment, and prognostic significance. Neurology. 1992 Jun; 42(6):1181-4.

14. Horton J, Means ED, Cunningham TJ, Olson KB. The numb chin in breast cancer. J Neurol Neurosurg Psychiatry. 1973 Apr; 36(2):211-216.

15. Harris CP, Baringer JR. The numb chin in metastatic cancer. West J Med. 1991 Nov;155(5): 528-31.

16. Miera C, Benito-León J, dela Fuente M, de la Serna J. Numb chin syndrome heralding mye-loma relapse. Muscle Nerve. 1997 Dec;20(12):1603-6.

17. Galán Gil S, Peñarrocha Diago M, Peñarrocha Diago M. Malignant mental nerve neuropathy: systematic review. Med Oral Patol Oral Cir Bu-cal. 2008 Oct 1;13(10):E616-21.

18. Kota G, Gupta P, Mintz A. PET/CT illustration of metastatic breast cancer to the left mandibu-lar foramen. Clin Nucl Med. 2013 May;38(5):385-6.

19. da Silva Simão DA, Murad M, Martins C, Fernandes VC, Captein KM, Teixeira AL. Chemotherapy-induced peripheral neuropathy: review for clinical practice. Rev Dor. São Paulo 2015 July-Sep;16(3):215-20.

20. Bar-Ziv J, Slasky BS. CT imaging of mental nerve neuropathy: the numb chin syndrome. AJR Am J Roentgenol. 1997 Feb;168(2):371-6.

21. Eppley BL, Snyders RV Jr. Mental neuropathy as a sign of distant malignancy: report of cases. J Oral Maxillofac Surg. 1992 Oct;50(10):1117-9.

22. Halachmi S, Madeb R, Madjar S, Wald M, River Y, Nativ O. Numb chin syndrome as the presenting symptom of metastatic prostate carcinoma. Urology. 2000 Feb;55(2):286.

23. Riesgo VJ, Delgado SR, Poveda J, Rammohan K. Numb chin syndrome secondary to leptomeningeal carcinomatosis from gastric adenocarcinoma. J Gastrointest Oncol. 2015 Apr; 6 (2):E16-20.

24. Hao S, Mata M, Glorioso JC, Fink DJ. Gene transfer to interfere with TNFalpha signaling in neuropathic pain. Gene Ther. 2007 Jul;14(13): 1010-6.

25. Yuan L, Neufeld AH. Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head. Glia. 2000 Oct;32 (1):42-50.

26. Lynch TJ, Harris NL. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 27-1994. A 41-year-old woman with neurologic abnormali-ties and an osteolytic lesion in the mandible. N Engl J Med. 1994 Jul;331(2):107-13.

27. García-Lamazares M, Ferreiro-Uriz O, Alfaya-García L. Numb chin syndrome as a sign of tumour recurrence. Semergen. 2013 Feb;40(2):e43-6.

28. Narendra H, Ray S. Numb chin syndrome as a manifestation of metastatic squamous cell carcinoma of esophagus. J Cancer Res Ther. 2009 Jan-Mar;5(1):49-51.

29. Chapa NJ. Numb chin syndrome: a signal of underlying concern. J Dent Hyg. 2014 Dec; 88(6): 348-52.

30. Massey EW, Moore J, Schold SC Jr. Mental neuropathy from systemic cancer. Neurology. 1981 Oct;31(10):1277-81.

31. Sierra-Hidalgo F, de Pablo-Fernández E, Correas-Callero E, Villarejo-Galende A. [Numb chin syndrome caused by biphosphonates-induced osteonecrosis of the jaw]. Rev Neurol. 2009 Aug 16-31;49(4):190-2.

32. Krukowski K, Nijboer CH, Huo X, Kavelaars A, Heijnen CJ. Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ. Pain. 2015 Nov; 156 (11):2184-92.

33. Assaf AT, Jürgens TP, Benecke AW, Riecke B, Blessmann M, Zrnc TA, et al. Numb chin syndrome: a rare and often overlooked symp-tom. J Oral Facial Pain Headache. 2014 Win-ter;28(1):80-90.

34. Zadik Y, Benoliel R, Fleissig Y, Casap N. Pain-ful trigeminal neuropathy induced by oral bisphosphonate-related osteonecrosis of the jaw: a new etiology for the numb-chin syn-drome. Quintessence Int. 2012 Feb;43(2):97-104.

35. Ward SJ, McAllister SD, Kawamura R, Murase R, Neelakantan H, Walker EA. Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminish-ing nervous system function or chemotherapy efficacy. Br J Pharmacol. 2014 Feb;171(3):636-45.

36. Ward PR, Wong MD, Moore R, Naeim A. Fall-related injuries in elderly cancer patients treated with neurotoxic chemotherapy: a retrospective cohort study. J Geriatr Oncol. 2014 Jan;5(1):57-64.

37. Park SB, Goldstein D, Krishnan AV, Lin CS, Friedlander ML, Cassidy J, et al. Chemothera-py-induced peripheral neurotoxicity: a critical analysis. CA Cancer J Clin. 2013 Non-Dec;63(6): 419-37.

38. Gornstein E, Schwarz TL. The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions. Neuropharmacology. 2014 Jan;76 Pt A:175-83.

39. Lin H, Heo BH, Yoon MH. A New Rat Model of Cisplatin-induced Neuropathic Pain. Korean J Pain. 2015 Oct;28(4):236-43.

40. Tejani N, Cooper A, Rezo A, Pranavan G, Yip D. Numb chin syndrome: a case series of a clin-ical syndrome associated with malignancy. J Med Imaging Radiat Oncol. 2014 Dec;58(6):700-5.

41. Sudha S, Gopinath D, Shameena PM, Dhanalakshmi J. Numb chin syndrome associ-ated with metastatic invasive ductal carcinoma of breast. J Oral Maxillofac Pathol. 2015 May-Aug; 19(2):239-41.

42. Oravivattanakul S, Coffey M, Teston L, Rogers LR. Teaching NeuroImages: "numb chin syndrome" in a patient with breast cancer. Neurology. 2013 Mar 19;80(12):e131.

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Agha-Hosseini F, Rohani B. Mental Neuropathy as Initial Manifestation of Metastatic Breast Cancer: A Case Report and Review of the Literature. J Iran Dent Assoc 2017; 29 (1) :36-43
URL: http://jida.ir/article-1-1907-en.html

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