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:: Volume 19, Issue 4 (Foll Text in Persian 2008) ::
J Iran Dent Assoc 2008, 19(4): 29-36 Back to browse issues page
Biocompatibility of eight different orthodontic materials: in-vivo rat model study
Sosan Sadeghian * 1, S. Mohammad Razavi , Ali reza Masaeli
1- , drsadeghian@yahoo.com
Abstract:   (15757 Views)

Biocompatibility of eight different orthodontic materials: in-vivo rat modl study

Dr. Sadeghian, S.* - Dr. Razavi, S.M. ** - Dr. Masaeli, A.***

*Assistant Professor of Orthodontics Dept., Faculty of Dentistry, Isfahan Azad University (Khorasgan).

**Assistant Professor of Pathology Dept., Faculty of Dentistry, Isfahan University of Medical Sciences.

***Dentist.

Abstract

Background & Aim: Different materials are used in orthodontic treatments. These materials are subjected to damp oral environment which can modify their properties. The purpose of this study was to evaluate the in-vivo biocompatibility of eight orthodontic materials, which were implanted in rat connective tissues.

Materials & Methods: Through an interventional experimental study, the biocompatibility of eight clinically used materials were evaluated. These materials were composed of two coil springs (S.L.S and NiTi), two glass ionomer cements (Bandtate and Ariadent), two O-ring (American ortho and Pooyan tebbe nour) as well as two orthodontic acrylic resins (Acropars and Bayer). Ninety-six white female rats were included in the study. Five sites were marked on the dorsal subdermal connective tissue of each rat, and then two pieces of each material measured at one centimeter long were implanted in the right side and two pieces of another material on the left. Also a similar incision was made at the two other marked sites, and then sutured, without inserting any material. Biopsies were taken from the specified sites, 15, 30 and 60 days following implantation. Tissue reactions were reported after microscopic evaluation, using the inflammation assessment chart. Non-parametric tests such as Kruskal-Wallis and Mann-Whitney tests were used for data analysis.

Results: This study demonstrated biocompatibility of acrylic resins and O-rings in the 15- and 30-day experiments. In the glass ionomer cement biopsies significant inflammatory reaction was detected In the 60-day experiment. Significant biocompatibility difference was observed between the coil springs groups (S.L.S-NiTi ) and controls In the 30 and 60-day experiments.

Conclusion: This study suggests that coil springs and glass ionomer cements can be considered as cytotoxic materials. Although, further studies are recommended in order to support these findings.

Key words: Biocompatibility - Orthodontic material - Connective tissue - Rat

Corresponding Author: Orthodontics Dept., Faculty of Dentistry, Isfahan Azad University (Khorasgan)

e.mail:drsadeghian@yahoo.com

Keywords: Biocompatibility, Orthodontic material, Connective tissue, Rat
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Type of Study: Research | Subject: General
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Sadeghian S, Razavi S M, Masaeli A R. Biocompatibility of eight different orthodontic materials: in-vivo rat model study. J Iran Dent Assoc 2008; 19 (4) :29-36
URL: http://jida.ir/article-1-284-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 19, Issue 4 (Foll Text in Persian 2008) Back to browse issues page
Journal of Iranian Dental Association

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This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

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