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:: Volume 19, Issue 4 (Foll Text in Persian 2008) ::
J Iran Dent Assoc 2008, 19(4): 37-42 Back to browse issues page
Biocompatibility comparison of two different sealers AH26 and Apexit: In-vivo animal model
Maryam Zare Jahromi * 1, S. Mohammad Razavi , Behrang Tabesh
1- , hiva1378maryam@yahoo.com
Abstract:   (13223 Views)

Biocompatibility comparison of two different sealers AH26 and Apexit: In-vivo animal model

Dr. Zare Jahromi, M.* - Dr. Razavi, S.M.** - Dr. Tabesh, B.***

*Assistant Professor of Endodontics Dept., Faculty of Dentistry, Isfahan Azad University (Khorasgan).

**Assistant Professor of Pathology Dept., Faculty of Dentistry, Isfahan University of Medical Sciences.

***Dentist.

Abstract

Background & Aim: There are a few conditions that prove a sealer to be suitable for use in practice. One of the important factors in a good sealer is its biocompatibility. The purpose of this in-vivo study was to compare the biocompatibility of two types of endodontic sealers AH26 and Apexit by using animal model.

Materials & Methods: A total of eleven white rats were included in this interventional in-vivo study. After sedation of rats, two sealers (AH26 and Apexit) were implanted in the subcutaneous tissue of each rat. AH26 was implanted in two sites of subcutaneous tissue in the left side and Apexit was implanted in two sites in the right side and the control site was designated in between them. In control group, the incisions were made similar to AH26 and Apexit groups and sutured without insertion of any material. Biopsies were taken from five rats after three days and from the other six rats after thirty days. Histological specimens were studied by pathologist and findings were reported. Data was analyzed using appropriate statistical procedures as well as Mann–Whitney and Kruskal-Wallis tests in order to report the significance level

Results: Although Apexit caused more inflammation compared to AH26, after 3 and 30 days, but such difference was not statistically significant (P>0.05). However, both sealers initiated mild to moderate inflammation when judged against control group and the difference was statistically significant (P<0.05).

Conclusion: Even though AH26 and Apexit cause inflammation in subcutaneous tissues of rats but they have moderate biocompatibility as the inflammation was graded two in this study according to the pathologic report.

Key word: Biocmpatibility – Sealers - AH26 – Apexit - Rat.

Corresponding Author: Endodontics Dept., Faculty of Dentistry, Isfahan Azad University (Khorasgan).

e.mail: hiva1378maryam@yahoo.com

Keywords: Biocmpatibility, Sealers, AH26, Apexit, Rat
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Type of Study: Research | Subject: General
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Zare Jahromi M, Razavi S M, Tabesh B. Biocompatibility comparison of two different sealers AH26 and Apexit: In-vivo animal model. J Iran Dent Assoc 2008; 19 (4) :37-42
URL: http://jida.ir/article-1-285-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 19, Issue 4 (Foll Text in Persian 2008) Back to browse issues page
Journal of Iranian Dental Association

AWT IMAGE

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

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