TY - JOUR T1 - Effect of locally delivered phenytoin 1% on improvement of chronic periodontitis parameters TT - اثر تجویز ژل فنی‌توئین 1٪ در بهبود پارامترهای پریودنتال در بیماران مبتلا به پریودنتیت مزمن JF - JIDA JO - JIDA VL - 20 IS - 4 UR - http://jida.ir/article-1-519-en.html Y1 - 2009 SP - 343 EP - 348 KW - Chronic Periodontitis KW - Phenytoin KW - Pocket Depth KW - Connective Tissue Attachment. N2 - Effect of locally delivered phenytoin 1% on improvement of chronic periodontitis parameters Dr. Abrishami MR.,1 Dr. Akbarzadeh-Bagheban A.,2 Dr. Ansari G.3 1 Assistant Professor, Department of Periodontology, Faculty of Dentistry, Shahid Beheshti University / MC. Tehran, Iran. 2 Assistant Professor, Department of Biostatistics, Paramedical college, Shahid Beheshti University / MC. Tehran, Iran.3 Associate Professor, Department of Pediatric Dentistry, Faculty of Dentistry, Shahid Beheshti University / MC. Tehran, Iran. (Received 20 Oct, 2007 Accepted 8 Jan, 2009) Abstract Background & Aim: Different adjunctive treatment options have been proposed for treating periodontal diseases other than standard scaling and root planning due to higher incidence of periodontal conditions. Phenytoin is a drug primarily used for the treatment of epilepsy. However, its positive effect on wound healing process has encouraged researchers to recommend it for patients with periodontitis. The aim of this study was to assess the effect of Phenytoin 1% gel in the improvement of periodontal parameters in chronic periodontitis. Materials & Methods: In an experimental split–mouth study, 18 patients with moderate periodontitis having at least 2 contra lateral teeth, pocket depth of 4-5 mm and no history of systemic disease were selected. After standard scaling and root planning treatment, both right or left side of the oral cavity was randomly assigned for local delivery of phenytoin 1% gel and, the other side was selected as control. Pocket depth (PD) and connective tissue adhesion (CTA) indices were assessed at the baseline and also two, four and eight weeks after the first injection. The data were analyzed using Repeated Measures ANOVA and Paired T-tests, considering the baseline measures as covariates. Results: Using baseline PD and CTA values as covariates, significant reduction was observed in mean PD (P M3 ER -