Iranian Dental Association Journal of Iranian Dental Association 3060-8201 18 1 2006 04 01 Comparison of Helioseal F microleakage with 37% phosphoric acid and self – etch primer (In - vitro) 85 90 EN Zahra Bahrololoomi Maryam Nyazmand Journal Article 2007 04 30 2013 02 25 Comparison of Helioseal F microleakage with 37% phosphoric acid and self – etch primer (In - vitro) Dr. Z. Bahrololoomi* - Dr. M. Nyazmand** *- Assistant Professor of Pedodontics Dept. - Faculty of Dentistry – Shaheed Sadoughi Yazd University of Medical Sciences. **- Dentist. Background and Aim: Recently, the use of self – etch primers, due to their ease of manipulation, for fissure sealant therapy is recommended. The aim of this study was to compare the microleakage of Helioseal F using two methods. Materials and Methods: In this in vitro study, 36 extracted intact human premolar teeth were randomly divided into two groups (n = 18) and were sealed with two methods: 1 – Conventional etching method. 2 – Using Prompt – Lpop acidic primer. All specimens were thermocycled for 1000 cycles at 5C – 55 C, then the teeth were immersed in 2% fuschin solution for 24 hours, sectioned and analyzed by stereomicroscopy. Data were subjected to Mann – Whitney test. Results:There was no statistically significant difference in microleakage of sealants between two methods(P= 0.869). Conclusion: In case of poor patient cooperation along with proper isolation, the use of self – etch primers is recommended for fissure sealant therapy. Key words: Fissure sealant – Microleakage – Self – etch primer.