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:: Volume 29, Issue 1 (1-2017) ::
J Iran Dent Assoc 2017, 29(1): 21-28 Back to browse issues page
Clinicopathologic Significance of P63, Maspin and MMP-2 Expression in Mucoepidermoid Carcinoma
Nasim Taghavi1 , Parisa Kardouni Khozestani * 2, Alireza Akbarzadeh Baghban3
1- Associate Professor, Oral & Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Assistant Professor, Department of Oral & Maxillofacial Pathology, School of Dentistry, Gilan University of Medical Sciences, Rasht, Iran , p.kardouni@gmail.com
3- Associate Professor PhD in Biostatistics, Associate Professor, Proteomics Research Center, Department of Basic Science, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (2847 Views)
Background and Aim: Mucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of the salivary glands with complex histopathologic features and clinical behavior. The aim of this study was to evaluate the clinicopathologic significance of p63, Maspin and matrix metalloproteinase (MMP)-2 expression in MEC.
Materials and Methods: In this retrospective study, immunohistochemical staining was performed to detect the expression of p63, Maspin and MMP-2 in 35 cases of MEC. In addition, to detect the presence of myoepithelial differentiation, smooth muscle actin (SMA) staining was performed. Data were analyzed using non-parametric tests.
Results: P63 expression, intensity of staining for p63 and MMP-2 total score showed significant correlations with histologic grade (P=0.008, P=0.035 and P=0.003, respectively). The association between p63 expression and MMP-2 total score was significant (P=0.033). P63 positive cases did not express SMA.
Conclusion: Findings suggest that p63 and MMP-2 may be useful prognostic indicators in MEC. MEC is devoid of myoepithelial cells.
Keywords: TP63 Protein, Human, SERPIN-B5, Matrix Metalloproteinase 2, Carcinoma, Mucoepidermoid
Full-Text [PDF 516 kb]   (1553 Downloads)    
Type of Study: Original | Subject: Pathology
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Taghavi N, Kardouni Khozestani P, Akbarzadeh Baghban A. Clinicopathologic Significance of P63, Maspin and MMP-2 Expression in Mucoepidermoid Carcinoma . J Iran Dent Assoc 2017; 29 (1) :21-28
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Volume 29, Issue 1 (1-2017) Back to browse issues page
Journal of Iranian Dental Association

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