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:: Volume 20, Issue 1 (Foll Text in Persian 2008) ::
J Iran Dent Assoc 2008, 20(1): 87-92 Back to browse issues page
Correlation between serum and un-stimulated whole saliva c-erbB-2 concentrations in women with breast cancer
Farzaneh Agha-Hosseini * 1, Eraj Mirzai-Dizgah , Asiyeh Rahimi
1- , e.mail:aghahose@sina.tums.ac.ir
Abstract:   (14512 Views)

Correlation between serum and un-stimulated whole saliva c-erbB-2 concentrations in women with breast cancer

 

 

Dr. Agha-Hosseini F.,1 Dr. Mirzai-Dizgah E.,2 Dr. Rahimi A.3

1Professor, Department of Oral Medicine. Dental Research Center, School of Dentistry, Medical Sciences / University of Tehran, Tehran, Iran. 2Assistant professor, Department of Physiology, School of Medicine, Army University of Medical Sciences, Tehran, Iran.

3Dentist, Private Practice, Tehran, Iran.

 

Abstract

Background & Aim: Human saliva can be easily obtained by non-invasive techniques. It contains many analytes of interest for screening, diagnosis and monitoring of normal and abnormal conditions. The protein c-erbB-2, also known as Her2/neu, is a prognostic breast cancer marker in women diagnosed with malignant tumors. The aim of this study was to assess the relationship between serum and saliva levels of c-erbB-2 in healthy women and untreated and treated patients with breast cancer.

Materials & Methods: A case-control study design was used for this investigation. A total of forty two women were included in the study. Participants were matched for age and were divided into three equal groups. The collected specimens were evaluated for the expression of c-erbB-2 levels in serum and unstimulated whole saliva by ELISA technique. The ANOVA and Pearson Correlation were used for data analyses.

Results: Significant lower unstimulated salivary flow rate was observed in untreated cases in comparison with healthy women. However, no significant difference was detected in whole saliva output, as well as serum and saliva concentration of c-erbB-2 between the three groups. The correlation of c-erbB-2 between serum and saliva concentrations (r=0.02) and between serum concentration and saliva output (r=0.18) were not statistically significant.

Conclusion: It seems that salivary and serum c-erbB-2 concentrations have no correlation in early stages of breast cancer and non-metastatic conditions.

Key words: Unstimulated whole saliva - Serum - c-erbB-2 - Breast cancer.

 

Corresponding Author: Dr. Agha-Hosseini F., Department of Oral Medicine. Dental Research Center, School of Dentistry, Medical Sciences / University of Tehran, Tehran Iran.

e.mail: aghahose@sina.tums.ac.ir

Keywords: Unstimulated whole saliva, Serum, c-erbB-2, Breast cancer.
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Type of Study: Research | Subject: General
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Agha-Hosseini F, Mirzai-Dizgah E, Rahimi A. Correlation between serum and un-stimulated whole saliva c-erbB-2 concentrations in women with breast cancer. J Iran Dent Assoc 2008; 20 (1) :87-92
URL: http://jida.ir/article-1-322-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 20, Issue 1 (Foll Text in Persian 2008) Back to browse issues page
Journal of Iranian Dental Association

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