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:: Volume 28, Issue 4 (10-2016) ::
J Iran Dent Assoc 2016, 28(4): 155-165 Back to browse issues page
Expression of Matrix Metalloproteinases 2 and 19 in Odontogenic Keratocysts and Dentigerous Cysts
Fatemeh Mashhadiabbas1 , Parisa Kardouni Khozestani * 2, Mojan Madani3 , Alireza Akbarzadeh Baghban4 , Sepanta Hosseinpour5
1- Associate Professor, Department of Oral & Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Assistant Professor, Department of Oral & Maxillofacial Pathology, School of Dentistry, Gilan University of Medical Sciences, Rasht, Iran , p.kardouni@gmail.com
3- Dentist, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- PhD in Biostatistics, Associate Professor, Proteomics Research Center, Department of Basic Science, School of Rehabilitation, Sha-hid Beheshti University of Medical Sciences, Tehran, Iran
5- Dental Student, Students Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (2697 Views)
Background and Aim: Odontogenic keratocyst (OKC) and dentigerous cyst (DC) are two common developmental cysts involving the jaws. The role of matrix metalloproteinases 2 (MMP2) and 19 (MMP19) in progression and invasion of some cysts and tumors has been documented. This study sought to assess the expression of MMP2 and MMP19 in OKCs and DCs.
Materials and Methods: In this descriptive analytical study, 58 paraffin blocks including 20 DCs, 20 OKCs and 18 dental follicles (DF) were chosen from the archives of the Oral and Maxillofacial Pathology Department, Shahid Beheshti University of Medical Sciences. Immunohistochemistry (IHC) staining was performed to detect the expression of MMP2 and MMP19 using the EnVision technique. Data were analyzed using the Chi square, Fisher’s exact, Kruskal Wallis, Mann Whitney and Spearman’s cor-relation tests.
Results: Both markers were expressed in OKCs and DCs. Expression of MMP19 was higher in OKCs compared to DCs and DFs. Significant differences existed among the groups in the intensity of staining of the epithelium (P<0.05) and the connective tissue (P<0.001) for MMP19. Expression of MMP2 in DCs was higher than in OKCs and DFs. Significant differences existed among the groups in the intensity and percentage of staining of the epithelium (P<0.001) and the connective tissue (P<0.05) for MMP2.
Conclusion: Our findings indicated the potential role of MMP19 in the invasive behavior of OKC. Greater expression of MMP2 in DCs may indicate its role in multi-dimensional growth of this cyst. Nevertheless, further studies are required to make an evidence-based decision.
Key Words: Odontogenic Cysts, Dentigerous Cyst, Matrix Metalloproteinases
Keywords: Odontogenic Cysts, Dentigerous Cyst, Matrix Metalloproteinases
Full-Text [PDF 505 kb]   (1210 Downloads)    
Type of Study: Original | Subject: Pathology
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Mashhadiabbas F, Kardouni Khozestani P, Madani M, Akbarzadeh Baghban A, Hosseinpour S. Expression of Matrix Metalloproteinases 2 and 19 in Odontogenic Keratocysts and Dentigerous Cysts. J Iran Dent Assoc 2016; 28 (4) :155-165
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Volume 28, Issue 4 (10-2016) Back to browse issues page
Journal of Iranian Dental Association

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