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:: Volume 22, Issue 1 (Foll Text in Persian 2010) ::
J Iran Dent Assoc 2010, 22(1): 35-41 Back to browse issues page
Angiogenesis in salivary gland mucoepidermoid carcinoma and its relation to histologic grading
Shahroo Etemad-Moghadam , Mojgan Alaeddini * 1, Bahareh Mozaffari
1- , e.mail:malaeddini@sina.tums.ac.ir
Abstract:   (13870 Views)

 Angiogenesis in salivary gland mucoepidermoid carcinoma and its relation to histologic grading

 

 Dr. Etemad-Moghadam SH ., 1 Dr. Alaeddini M ., 1 Dr. Mozaffari B .2

  

  1 Dental Research Center, Tehran University of Medical Sciences. Tehran, Iran.  2 Dentist.

  

  (Received 30 Nov, 2009 Accepted 21 April, 2010)

  

  Abstract

  

  Background and Aim : Angiogenesis is known as the outgrowth of new blood vessels from preexisting vasculature and plays an important role in different aspects of tumor growth and metastasis. Microvessel density (MVD) represents angiogenesis in neoplastic tissues and is generally employed as a useful tool for its measurement. The aim of the present study was to evaluate MVD in salivary gland mucoepidermoid carcinomas (MECs) and to assess its relation to histologic grade.

  Materials and Method : In this cross-sectional study, 30 parotid and minor salivary MECs were graded under a light microscope according to the AFIP criteria. All specimens were immunohistochemically stained with monoclonal antibody against CD34. MVD was determined by counting all positively-stained cells or cell clusters in 10 high-power-fields, selected from the most vascularized areas. The results were analyzed using one-way ANOVA and Scheffe post-hoc tests.

  Results : MVD was expressed as the mean number of microvessels per high-power-field. A statistically significant correlation was observed between MVD and MEC grade (P=0.001). Microvessel density was significantly lower in grades I (11.12) and II (13.66) compared to grade III (23.50) tumors. The difference between grades I and II neoplasms was not significant (P=0.725).

  Conclusions : According to the results obtained in the present study angiogenesis may have an important role in the pathogenesis of parotid and minor salivary gland MEC and may be useful in the prediction of its biologic behavior.

  Key words : Mucoepidermoid carcinoma – Angiogenesis - CD34.

  

  Corresponding Author : Dr. Alaeddini M . Dental Research Center, Tehran University of Medical Sciences. Tehran, Iran .  

  e.mail: malaeddini@sina.tums.ac.ir

 

Keywords: Mucoepidermoid carcinoma, Angiogenesis, CD34.
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Type of Study: Research | Subject: Pathology
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Etemad-Moghadam S, Alaeddini M, Mozaffari B. Angiogenesis in salivary gland mucoepidermoid carcinoma and its relation to histologic grading. J Iran Dent Assoc 2010; 22 (1) :35-41
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 22, Issue 1 (Foll Text in Persian 2010) Back to browse issues page
Journal of Iranian Dental Association

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This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

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