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:: Volume 26, Issue 1 (1-2014) ::
J Iran Dent Assoc 2014, 26(1): 50-63 Back to browse issues page
Effect of Mechanical Stimulation on Differentiation of Human Mesenchymal Stem Cells to Different Cell Lines: A Systematic Review
Fahime sadat Tabatabaei *1, Marziyeh Bordbar2
1- Assistant Professor, Department of Dental Materials, School of Dentistry, Shahid Beheshti University of Medical Sciences. Tehran, Iran , f.tabatabaei@sbmu.ac.i
2- Dentist
Abstract:   (8367 Views)

Background and Aim: Stem cells due to their great potential can help in establishing tissue engineering as a new treatment modality . Numerous studies have evaluated the effect of various chemical and mechanical stimuli on these cells. In this respect, the role of mechanical loads is undeniable. This systematic review evaluated studies on the effects of mechanical loads on differentiation of mesenchymal stem cells to different cell lineages published in the past 12 years .

  Materials and Methods: In this systematic review, PUBMED database was used to search key words namely “human mesenchymal stem cell”, “strain,”, “mechanical loading,” and “differentiation”, in the literature published from 2000 to July 2012. The inclusion criteria were the publication year, language of articles, type of cells and study objectives .

  Results: In total, 46 articles were evaluated qualitatively . In most studies, applied mechanical loads led to the anticipated differentiation. Studies showed that the combination of two forces increased differentiation. The a mount of applied strain also influenced the type of differentiation .

  Conclusion: This review indicated that advances made on the effects of mechanical loads on stem cells can be used for improving tissue engineering treatments . 

Keywords: Human Mesenchymal stem cells, Strain, Mechanical loading, Differentiation
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Type of Study: Review | Subject: Dental Materials
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Tabatabaei F S, Bordbar M. Effect of Mechanical Stimulation on Differentiation of Human Mesenchymal Stem Cells to Different Cell Lines: A Systematic Review. J Iran Dent Assoc 2014; 26 (1) :50-63
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Volume 26, Issue 1 (1-2014) Back to browse issues page
Journal of Iranian Dental Association


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