[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Journal Information::
About the Journal
Aim & Scope
Editorial Board
Indexing & Abstracting
Advertising Policy
Editorial Policies::
Peer Review Process
Section Policies
Open Access Policy
Ethical Requirements
Publication Ethics
Plagiarism Policy
Article Processing Charges (APC)
Authorship Conflicts
Intellectual Properties
Articles archive::
All Issues
Current Issue
For Authors::
Online Submmision
Instruction to Authors
Peer review process
Publication Ethics
Contact us::
Contact Information
Contact us
Site Facilities::
Site map
Search contents
Top 10 contents
Inform to friends
::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Last site contents
:: Contact Us
:: Volume 28, Issue 3 (7-2016) ::
J Iran Dent Assoc 2016, 28(3): 104-109 Back to browse issues page
Alcohol Induced Osteopenia Can Cause Accelerated Orthodontic Tooth Movement in Male Wistar Rats
Mohammad Sadegh Ahmad Akhoundi1 , Amirhossein Mirhashemi2 , Sedigheh Sheikhzadeh * 3, Elahe Ansari4 , Yasaman Kheirandish5 , Nafiseh Momeni6 , Mohmmad Javad Khaarazifard7
1- Professor, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran AND Department of Orthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
2- Associate Professor, Department of Orthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
3- Assistant Professor, Oral Health Research Center, Institute of Health, Babol University of Medical Sciences, Babol, Iran AND Department of Orthodontics, School of Dentistry, Babol University of Medical Sciences, Babol, Iran , elfsh@yahoo.com
4- Dentist, Private Office, Tehran, Iran
5- Assistant Professor, Department of Oral and Maxillofacial Radiology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
6- Dentist, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
7- Research Member, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (2840 Views)
Background and Aim: Considering the effect of alcohol on bones, consuming alcohol may have some consequences on orthodontic tooth movement. The present study was aimed to evaluate the effect of alcohol consumption on bone density and orthodontic tooth movement in rats.
Materials and Methods: In this experimental study, thirty rats were divided into three groups and underwent 3 weeks of different injection regimen. Group A received no injection while rats in group B and C were infused with saline and a mixture of alcohol and saline respectively. Tooth movement at day 21 was measured by leaf gauge. Optical density was measured using a digital densitometer at the beginning and the end of the experiment around four lateral cephalometric landmarks. One-way analysis of variance (ANOVA) was used to determine the differences in tooth movement. Changes in bone density were analyzed using paired T-test after evaluation of interactions.
Results: Mean tooth movement in group C was (0.4± 0.06 mm) was significantly higher than no injection (0.26 ± 0.04 mm) and saline infusion (0.29 ± 0.04 mm) groups (P=0.001). Significant decrease in bone density were observed in alcohol injected group in skull (P=0.005) and mandible(P=0.004) after three weeks of experiment.
Conclusion: Alcohol infusion could induce decreased bone density which might be a reason for faster tooth movement in alcohol-treated rats.
 
Keywords: Ethanol, Bone density, Tooth, Rats
Full-Text [PDF 359 kb]   (1061 Downloads)    
Type of Study: Original | Subject: Orthodontics
References
1. Marrone JA, Maddalozzo GF, Branscum AJ, Hardin K, Cialdella-Kam L, Philbrick KA, et al. Moderate alcohol intake lowers biochemical markers of bone turnover in postmenopausal women. Menopause. 2012 Sep; 19(9):974-9.
2. Johnson TL, Gaddini G, Branscum AJ, Olson DA, Caroline-Westerlind K, Turner RT, et al. Effects of chronic heavy alcohol consumption and endurance exercise on cancellous and cor-tical bone microarchitecture in adult male rats. Alcohol Clin Exp Res. 2014 May;38(5):1365-72.
3. GaddiniGW, Grant KA, Woodall A, Stull C, Maddalozzo GF, Zhang B, et al. Twelve months of voluntary heavy alcohol consumption in male rhesus macaques suppresses intracortical bone remodeling. Bone. 2015 Feb;71:227-36.
4. Suh KT, Kim SW, Roh HL, Youn MS, Jung JS. Decreased osteogenic differentiation of mesencymal stem cells in alcohol-induced osteonecrosis. Clin Orthop Relat Res. 2005 Feb; (431):220-5.
5. Klein RF, Fausti KA, Carlos AS. Ethanol inhibits human osteoblastic cell proliferation. Alcohol Clin Exp Res. 1996 May;20(3):572-8.
6. Mikosch P. Alcohol and bone. Wien Med Wochenschr. 2014 Jan;164(1-2):15-24.
7. Tucker KL1, Jugdaohsingh R, Powell JJ, Qiao N, Hannan MT, Sripanyakorn S, et al. Effects of beer, wine, and liquor intakes on bone min-eral density in older men and women. Am J Clin Nutr. 2009 Apr;89(4):1188-96.
8. Talaeipour AR, Shirazi M, Kheirandish Y, Delrobaie A, Jafari F, Dehpour AR. Densito-metric evaluation of skull and jaw bones after administration of thyroid hormones in rats. Dentomaxillofac Radiol. 2005 Nov;34(6):332-6.
9. Horner K, Devlin H, Alsop CW, Hodgkinson IM, Adams JE. Mandibular bone mineral densi-ty as a predictor of skeletal osteoporosis. Br J Radiol. 1996 Nov;69(827):1019-25.
10. Guide for the care and use of laboratory animals. Available at: https://grants.nih.gov/grants/olaw/guide-for-the-care-and-use-of-laboratory-animals.pdf/Accessed March 10, 2016.
11. Akhoundi MS, Dehpour AR, Rashidpour M, Alaeddini M, Kharazifard MJ, Noroozi H. The effect of morphine on orthodontic tooth move-ment in rats. Aust Orthod J. 2010 Nov;26(2):113-8.
12. Rashidpour M, Ahmad Akhoundi MS, Nik TH, Dehpour A, Alaeddini M, Javadi E, et al. Effect of Tramadol (μ-opioid receptor agonist) on orthodontic tooth movements in a rat model. J Dent (Tehran). 2012 Spring;9(2):83-9.
13. Mir Hashemi AH, Afshari M, Alaeddini M, Etemad-Moghadam S, Dehpour A, Sheikhzade S, et al. Effect of atorvastatin on orthodontic tooth movement in male Wistar rats. J Dent (Tehran). 2013 Nov;10(6):532-9.
14. Mirhashemi AH, Ahmad Akhoundi MS, Sheikhzadeh S, Momeni N, Dehpour A, Alaed-dini M, et al. Effect of fluoxetine consumption on orthodontic tooth movement in rats. J Dent (Tehran). 2015 Dec;12(12):882-9.
15. Ahmad Akhoundi MS, Ghazanfari R, Etemad-Moghadam S, Alaeddini M, Khorshidi-an A, Rabbani S, et al. Effect of supplementary zinc on orthodontic tooth movement in a rat model. Dental Press J Orthod. 2016 Mar-Apr; 21(2):45-50.
16. Sampson HW, Hebert VA, Booe HL, Champney TH. Effect of alcohol consumption on adult and aged bone: composition, morphol-ogy, and hormone levels of a rat animal model. Alcohol Clin Exp Res. 1998 Nov;22(8):1746-53.
17. Sampson HW, Perks N, Champney TH, DeFee B 2nd. Alcohol consumption inhibits bone growth and development in young actively growing rats. Alcohol Clin Exp Res. 1996 Nov;20(8):1375-84.
18. Nishiguchi S, Shiomi S, Tamori A, Habu D, Takeda T, Tanaka T,et al. Effect of ethanol on bone mineral density of rats evaluated by dual-photon X-ray absorptiometry. J Bone Min-er Metab. 2000;18(6):317-20.
19. Nyquist F, Halvorsen V, Madsen JE, Nordsletten L, Obrant KJ. Ethanol and its ef-fects on fracture healing and bone mass in male rats. Acta Orthop Scand. 1999 Apr;70(2):212-6.
20. Iwaniec UT, Turner RT. Intraperitoneal injection of ethanol results in drastic changes in bone metabolism not observed when ethanol is administered by oral gavage.Alcohol Clin Exp Res. 2013 Aug;37(8):1271-7.
21. Desimone DP, Greene VS, Hannon KS, Turner RT, Bell NH. Prostaglandin E2 administered by subcutaneous pellets causes local inflammation and systemic bone loss: a model for inflamma-tion-induced bone disease. J Bone Miner Res. 1993 May; 8(5):625-34.
22. Boé DM, Richens TR, Horstmann SA, Burnham EL, Janssen WJ, Henson PM, et al. Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response. Alcohol Clin Exp Res. 2010 Oct;34(10):1723-32.
23. Maddalozzo GF, Turner RT, Edwards CH, Howe KS, WidrickJJ, Rosen CJ, et al. Alcohol alters whole body composition, inhibits bone formation, and increases bone marrow adiposity in rats. Osteoporos Int. 2009 Sep;20(9):1529-38.
24. Chavassieux P, Serre CM, Vergnaud P, Delmas PD, Meunier PJ. In vitro evaluation of dose-effects of ethanol on human osteoblastic cells. Bone Miner. 1993 Aug;22(2):95-103.
25. Sun T, Deng Z, Zhu Y. Effects of insulin-like growth factor 1 on inhibition of osteoblastic proliferation and function by ethanol. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007 Dec;21(12):1338-41.
26. Maurel DB, Jaffre C, Rochefort GY, Aveline PC, Boisseau N, Uzbekov R, et al. Low bone accrual is associated with osteocyte apoptosis in alcohol-induced osteopenia. Bone. 2011 Sep; 49 (3):543-52.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Ahmad Akhoundi M S, Mirhashemi A, Sheikhzadeh S, Ansari E, Kheirandish Y, Momeni N et al . Alcohol Induced Osteopenia Can Cause Accelerated Orthodontic Tooth Movement in Male Wistar Rats. J Iran Dent Assoc 2016; 28 (3) :104-109
URL: http://jida.ir/article-1-1871-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 28, Issue 3 (7-2016) Back to browse issues page
Journal of Iranian Dental Association

AWT IMAGE

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly
Persian site map - English site map - Created in 0.06 seconds with 37 queries by YEKTAWEB 4645