Submitted: 22 Jul 2012
Accepted: 28 Sep 2014
ePublished: 28 Sep 2014
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J Iran Dent Assoc. 2012;24(3): 122-138.
  Abstract View: 18

Original

Effects of Different Growth Factors on New Bone Formation: A Systematic Review

Hosain Behnia, Arash Khojasteh*, Mohammad Esmaeelinejad, Navid Naghdi
*Corresponding Author: Email: arashkhojasteh@gmail.com

Abstract

  Background and Aim: Using different osteogenic growth factors, which is still under investigation, is a favorable method for bone regeneration. This systematic review is aimed at evaluating the effects of different growth factors and their carriers on osteogenesis .

  Materials and Methods: Electronic databases (Medline, EMBase and Cochrane) were studied by the authors for articles published from 1999 to October 2010. Clinical and animal studies evaluating bone formation by applying a specific growth factor and the related carrier were included in this investigation. Obtained data were organized in a table and evaluated through a qualitative analysis .

  Results: Sixty-nine studies most of which evaluated the effects of BMP-2 osteogenesis in different models were included in this study. Totally, twenty-five carriers were applied with different growth factors in the experiments. Among these carriers, poly lactic– co glycolic acid (PLGA), hydroxy apatite/tricalcium phosphate/absorbable collagen sponge (HA/TCP/ACS) and BioOss were the most frequently used carriers with the growth factors in bone regeneration studies.

  Conclusion: The current evidence, although not strong enough, confirms that BMP-2 has more favorable results in osteogenesis compared with other factors. The carrier scaffold, methods of measurement (histologic or radiographic), type of animal, defect diameter and the length of follow-up are the variables that should be matched before reaching definite results for the effect of growth factors in bone regeneration .

 

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