Abstract
Therapeutic assessment of Antrokinon on minor oral aphthous lesions
Dr. Hoseinpour-Jajarm H., 1 Dr. Banihashem-Rad SA., 2 Dr. Mirdamadi SJ.3
1Associate Professor, Department of Oral Medicine, Faculty of Dentistry, Dental Research Center, Mashhad University of Medical Sciences. Mashhad, Iran. 2Assistant Professor, Department of Periodontology, Faculty of Dentistry, Dental Research Center, Mashhad university of Medical Sciences. Mashhad, Iran. 3Assistant Professor of Faculty Pharmacy, Mashhad university of Medical Sciences. Mashhad, Iran.
Abstract
Background & Aim: Antrokinon is an herbal compound with anti-inflammatory properties. This substance is usually used for treatment of skin lesions and burns. The aim of this study was to assess the clinical therapeutic effects of Antrokinon on oral aphthous lesions.
Materials & Methods: In a double blind clinical trial study, the therapeutic effect of Antrokinon was evaluated against placebo in 80 individuals attending the school of Dentistry, Mashhad University of Medical Sciences. To receive dental treatment. The Antrokinon and placebo were exactly similar in color and they were in drop form (5cc). Five drops of drug or placebo were instructed to be used locally, 4 times a day, in regular intervals. The collected data was analyzed using Mann-Whitney U test at 95% confidence level (P≤0.05).
Results: The statistical analysis showed that, the drug had positive effects on clinical improvement of aphthous lesions in the oral cavity when compared with placebo. A significant decrease in clinical wound healing time was observed after using the drug in comparison with placebo (P=0.001). Likewise, Mann-Whitney U test revealed that the, burn-healing time was significantly shortened in comparison with placebo group as well (P=0.003).
Conclusion: Useing Antrokinon can significantly decrease both, the wound-healing time and burn-healing period in oral aphthous lesions.
Key words: Aphthous - Antrokinon.
Corresponding Author: Dr. Hoseinpour-Jajarm H., Department of Oral Medicine, Faculty of Dentistry, Dental Research Center, Mashhad University of Medical Sciences. Mashhad, Iran.
e.mail: h-hoseinpourj@yahoo.com